Selected publications

Single-cell DNA and surface protein characterization of high hyperdiploid acute lymphoblastic leukemia at diagnosis and during treatment - Aertgeerts M, Meyers S, Gielen O, Lamote J, Dewaele B, Tajdar M, Maertens J, De Bie J, De Keersmaecker K, Boeckx N, Michaux L, Uyttebroeck A, Demeyer S, Segers H, Cools J - Hemasphere - Pubmed

TLE4 is a repressor of the oncogenic activity of TLX3 in T-cell acute lymphoblastic leukemia - Lauwereins L, Van Thilo Q, Demeyer S, Mentens N, Provost S, Jacobs K, Gielen O, Boogaerts L, de Bock CE, Andrieu G, Asnafi V, Cools J, Veloso A - Leukemia - Pubmed

Single-cell CRISPR screening characterizes transcriptional deregulation in T-cell acute lymphoblastic leukemia - Meyers S, Gielen O, Cools J, Demeyer S - Haematologica - Pubmed

Unlocking the Complexity: Exploration of Acute Lymphoblastic Leukemia at the Single Cell Level - Aertgeerts M, Meyers S, Demeyer S, Segers H, Cools J - Molecular diagnosis & therapy - Pubmed

Selective targeting of malignant T cells - de Bock CE, Cools J - Nature Cancer - Pubmed

Single cell RNA sequencing reveals endothelial cell killing and resolution pathways in experimental malaria-associated acute respiratory distress syndrome - Pollenus E, Possemiers H, Knoops S, Prenen F, Vandermosten L, Thienpont C, Abdurahiman S, Demeyer S, Cools J, Matteoli G, Vanoirbeek JAJ, Vande Velde G, Van den Steen PE - Plos pathogens - Pubmed

The unexpected and unresolved roles of PDGFRA and PDGFRB in T-cell acute lymphoblastic leukemia - Verhoeft K, Cools J - Haematologica - Pubmed

A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling - Altea-Manzano P, Doglioni G, Liu Y, Cuadros AM, Nolan E, Fernández-García J, Wu Q, Planque M, Laue KJ, Cidre-Aranaz F, Lia X-Z, Marin-Bejar O, Van Elsen J, Vermeire I, Broekaert D, Demeyer S, Spotbeen X, Idkowiak J, Montagne A, Demicco M, Alkan HF, Rabas N, Riera-Domingo C, Richard F, Geukens T, De Schepper M, Leduc S, Hatse S, Lambrechts Y, Kay EJ, Lilla S, Alekseenko A, Geldhof V, Boeckx B, de la Calle Arregui C, Floris G, Swinnen JV, Marine J-C, Lambrechts D, Pelechano V, Mazzone M, Zanivan S, Cools J, Wildiers H, Baud V, Grünewald TGP, Ben-David U, Desmedt C, Malanchi I, Fendt S-M - Nature Cancer - Pubmed

Targeting STAT5B in T-cell acute lymphoblastic leukemia - Veloso A, Cools J - Blood - Pubmed

Transcription factor NKX2-1 drives serine and glycine synthesis addiction in cancer - Heylen E, Verstraete P, Van Aerschot L, Geeraerts SL, Venken T, Timcheva K, Nittner D, Verbeeck J, Royaert J, Gijbels M, Uyttebroeck A, Segers H, Lambrechts D, Cools J, De Keersmaecker K, Kampen KR - British Journal of Cancer - Pubmed

CRISPR screening in hematology research: from bulk to single-cell level - Meyers S, Demeyer S, Cools J - Journal of Hematology & Oncology - Pubmed

Combination therapy of a PSEN1-selective γ-secretase inhibitor with dexamethasone and an XPO1 inhibitor to target T-cell acute lymphoblastic leukemia - Vandersmissen C, Prieto C, Gielen O, Jacobs K, Nittner D, Maertens J, Segers H, Cools J - Haematologica - Pubmed

PHGDH heterogeneity potentiates cancer cell dissemination and metastasis - Rossi M, Altea-Manzano P, Demicco M, Doglioni G, Bornes L, Fukano M, Vandekeere A, Cuadros AM, Fernández-García J, Riera-Domingo C, Jauset C, Planque M, Alkan HF, Nittner D, Zuo D, Broadfield LA, Parik S, Pane AJ, Rizzollo F, Rinaldi G, Zhang T, Teoh ST, Aurora AB, Karras P, Vermeire I, Broekaert D, Van Elsen J, Knott MML, Orth MF, Demeyer S, Eelen G, Dobrolecki LE, Bassez A, Van Brussel T, Sotlar K, Lewis MT, Bartsch H, Wuhrer M, van Veelen P, Carmeliet P, Cools J, Morrison SJ, Marine J-C, Lambrechts D, Mazzone M, Hannon GJ, Lunt SY, Grünewald TGP, Park M, van Rheenen J, Fendt S-M - Nature - Pubmed

The Updated European Hematology Association Research Roadmap - Engert A, Cerisoli F, Cools J - Hemasphere - Pubmed

TAL1 cooperates with PI3K/AKT pathway activation in T-cell acute lymphoblastic leukemia - Thielemans N, Demeyer S, Mentens N, Gielen O, Provost S, Cools J - Haematologica - Pubmed 

Optimizing the diagnostic workflow for acute lymphoblastic leukemia by optical genome mapping - Rack K, De Bie J, Ameye G, Gielen O, Demeyer S, Cools J, De Keersmaecker K, Vermeesch J, Maertens J, Segers H, Michaux L, Dewaele B - American journal of hematology - Pubmed

Primary mediastinal large B-cell lymphoma is characterized by large-scale copy-neutral loss of heterozygosity - Tuveri S, Debackere K, Marcelis L, Dierckxsens N, Demeulemeester J, Dimitriadou E, Dierickx D, Lefesvre P, Deraedt K, Graux C, Michaux L, Cools J, Tousseyn T, Vermeesch JR, Wlodarska I - Genes, Chromosomes & Cancer - Pubmed

Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters - van Gils N, Verhagen HJMP, Broux M, Martiáñez T, Denkers F, Vermue E, Rutten A, Csikós T, Demeyer S, Çil M, Al M, Cools J, Janssen JJWM, Ossenkoppele G, Menezes RX, Smit L - iScience - Pubmed

Aberrant MYCN expression drives oncogenic hijacking of EZH2 as a transcriptional activator in peripheral T-cell lymphoma - Vanden Bempt M, Debackere K, Demeyer S, Van Thilo Q, Meeuws N, Prieto C, Provost S, Mentens N, Jacobs K, Gielen O, Nittner D, Ogawa S, Kataoka K, Graux C, Tousseyn T, Cools J, Dierickx D - Blood - Pubmed

Monitoring of Leukemia Clones in B-cell Acute Lymphoblastic Leukemia at Diagnosis and During Treatment by Single-cell DNA Amplicon Sequencing - Meyers S, Alberti-Servera L, Gielen O, Erard M, Swings T, De Bie J, Michaux L, Dewaele B, Boeckx N, Uyttebroeck A, De Keersmaecker K, Maertens J, Segers H, Cools J, Demeyer S - Hemasphere - Pubmed

Oncogenic Cooperation Between IL7R-JAK-STAT Pathway Mutations - Lodewijckx I, Mentens N, Jacobs K, Cools J - Hemasphere - Pubmed

Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia - Van Thillo Q, De Bie J, Seneviratne JA, Demeyer S, Omari S, Balachandran A, Zhai V, Tam WL, Sweron B, Geerdens E, Gielen O, Provost S, Segers H, Boeckx N, Marshall GM, Cheung BB, Isobe K, Kato I, Takita J, Amos TG, Deveson IW, McCalmont H, Lock RB, Oxley EP, Garwood MM, Dickins RA, Uyttebroeck A, Carter DR, Cools J, de Bock CE - 2021 - Nat Commun - Pubmed

PSEN1-selective gamma-secretase inhibition in combination with kinase or XPO-1 inhibitors effectively targets T cell acute lymphoblastic leukemia - Govaerts I, Prieto C, Vandersmissen C, Gielen O, Jacobs K, Provost S, Nittner D, Maertens J, Boeckx N, De Keersmaecker K, Segers H, Cools J - 2021 - J Hematol Oncol - Pubmed

Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified - Debackere K, Marcelis L, Demeyer S, Vanden Bempt M, Mentens N, Gielen O, Jacobs K, Broux M, Verhoef G, Michaux L, Graux C, Wlodarska I, Gaulard P, de Leval L, Tousseyn T, Cools J, Dierickx D. - 2021 - Nat Commun - Pubmed

Deregulation of the Interleukin-7 Signaling Pathway in Lymphoid Malignancies - Lodewijckx I, Cools J - 2021 - Pharmaceuticals - Pubmed

Single-cell DNA amplicon sequencing reveals clonal heterogeneity and evolution in T-cell acute lymphoblastic leukemia - Albertí-Servera L, Demeyer S, Govaerts I, Swings T, De Bie J, Gielen O, Brociner M, Michaux L, Maertens J, Uyttebroeck A, De Keersmaecker K, Boeckx N, Segers H, Cools J. - 2021 - Blood - Pubmed

MAPK-ERK is a central pathway in T-cell acute lymphoblastic leukemia that drives steroid resistance - van der Zwet JCG, Buijs-Gladdines JGCAM, Cordo V, Debets DO, Wmits WK, Chen Z, Dylus J, Zaman GJR, Altelaar M, Oshima K, Bornhauser B, Bourquin J-P, Cools J, Ferrando AA, Vormoor J, Pieters R, Vormoor B, Meijerink JPP - 2021 - Leukemia - Pubmed 

The XPO1 Inhibitor KPT-8602 Synergizes with Dexamethasone in Acute Lymphoblastic Leukemia - Verbeke D, Demeyer S, Prieto C, de Bock CE, De Bie J, Gielen O, Jacobs K, Mentens N, Verhoeven BM, Uyttebroeck A, Boeckx N, De Keersmaecker K, Maertens J, Segers H, Cools J - 2020 - Clin Cancer Res - Pubmed

Single-cell DNA amplicon sequencing reveals clonal heterogeneity and evolution in T-cell acute lymphoblastic leukemia - Albertí-Servera L, Demeyer S, Govaerts I, Swings T, De Bie J, Gielen O, Brociner M, Michaux L, Maertens J, Uyttebroeck A, De Keersmaecker K, Boeckx N, Segers H, Cools J - 2020 - Blood - Pubmed

Open Access is the Plan S Way Forward in Hematology Research - Cools J, Engert A, Gribben J, Macintyre E- 2020 - Hemasphere - Pubmed

FER and FES tyrosine kinase fusions in follicular T-cell lymphoma - Debackere K, van der Krogt JA, Tousseyn T, Ferreiro JAF, Van Roosbroeck K, Marcelis L, Graux C, Dierickx D, Ameye G, Vandenberghe P, Michaux L, Cools J, Wlodarska I - 2020 - Blood - Pubmed

JAK/STAT Pathway Mutations in T-ALL, Including the STAT5B N642H Mutation, are Sensitive to JAK1/JAK3 Inhibitors - Govaerts I, Jacobs K, Vandepoel R, Cools J. - 2019 - Hemasphere - Pubmed

Ruxolitinib Synergizes With Dexamethasone for the Treatment of T-cell Acute Lymphoblastic Leukemia - Verbeke D, Gielen O, Jacobs K, Boeckx N, De Keersmaecker K, Maertens J, Uyttebroeck A, Segers H, Cools J. - 2019 - Hemasphere - Pubmed

Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia - Broux M, Prieto C, Demeyer S, Vanden Bempt M, Alberti-Servera L, Lodewijckx I, Vandepoel R, Mentens N, Gielen O, Jacobs K, Geerdens E, Vicente C, de Bock CE, Cools J - 2019 - Blood - Pubmed

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition - Habets RA, de Bock CE, Serneels L, Lodewijckx I, Verbeke D, Nittner D, Narlawar R, Demeyer S, Dooley J, Liston A, Taghon T, Cools J, de Strooper B. - 2019 - Sci Transl Med - Pubmed

Fratricide-resistant CD1a-specific CAR T cells for the treatment of cortical T-cell acute lymphoblastic leukemia - Sánchez-Martínez D, Baroni ML, Gutierrez-Agüera F, Roca-Ho H, Blanch-Lombarte O, González-García S, Torrebadell M, Junca J, Ramírez-Orellana M, Velasco-Hernández T, Bueno C, Fuster JL, Prado JG, Calvo J, Uzan B, Cools J, Camos M, Pflumio F, Toribio ML, Menéndez P - 2019 - Blood - Pubmed

T-cell acute lymphoblastic leukemias express a unique truncated FAT1 isoform that cooperates with NOTCH1 in leukemia development - de Bock CE, Down M, Baidya K, Sweron B, Boyd AW, Fiers M, Burns GF, Molloy TJ, Lock RB, Soulier J, Taghon T, Van Vlierberghe P, Cools J, Holst J, Thorne RF - 2019 - Haematologica - Pubmed
 

The CCR4-NOT complex is a tumor suppressor in Drosophila melanogaster eye cancer models - Vicente C, Stirparo R, Demeyer S, de Bock CE, Gielen O, Atkins M, Yan J, Halder G, Hassan BA, Cools J. - 2018 - J Hematol Oncol - Pubmed

Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia - Vanden Bempt M, Demeyer S, Broux M, De Bie J, Bornschein S, Mentens N, Vandepoel R, Geerdens E, Radaelli E, Bornhauser BC, Kulozik AE, Meijerink JP, Bourquin JP, de Bock CE, Cools J. - 2018 - Cancer Cell - Pubmed

Single-cell sequencing reveals the origin and the order of mutation acquisition in T-cell acute lymphoblastic leukemia - De Bie J, Demeyer S, Alberti-Servera L, Geerdens E, Segers H, Broux M, De Keersmaecker K, Michaux L, Vandenberghe P, Voet T, Boeckx N, Uyttebroeck A, Cools J. - 2018 - Leukemia - Pubmed

HOXA9 Cooperates with Activated JAK/STAT Signaling to Drive Leukemia Development - de Bock CE, Demeyer S, Degryse S, Verbeke D, Sweron B, Gielen O, Vandepoel R, Vicente C, Vanden Bempt M, Dagklis A, Geerdens E, Bornschein S, Gijsbers R, Soulier J, Meijerink JP, Heinäniemi M, Teppo S, Bouvy-Liivrand M, Lohi O, Radaelli E, Cools J. - 2018 - Cancer Discov - Pubmed

Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia - Degryse S, de Bock CE, Demeyer S, Govaerts I, Bornschein S, Verbeke D, Jacobs K, Binos S, Skerrett-Byrne DA, Murray HC, Verrills NM, Van Vlierberghe P, Cools J, Dun MD. - 2018 - Leukemia - Pubmed

The Second-Generation Exportin-1 Inhibitor KPT-8602 Demonstrates Potent Activity against Acute Lymphoblastic Leukemia - Vercruysse T, De Bie J, Neggers JE, Jacquemyn M, Vanstreels E, Schmid-Burgk JL, Hornung V, Baloglu E, Landesman Y, Senapedis W, Shacham S, Dagklis A, Cools J, Daelemans D. - 2017 - Clin Cancer Res - Pubmed

The genetics and molecular biology of T-ALL - Girardi T, Vicente C, Cools J, De Keersmaecker K. - 2017 - Blood - Pubmed

Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors - Dagklis A, Demeyer S, De Bie J, Radaelli E, Pauwels D, Degryse S, Gielen O, Vicente C, Vandepoel R, Geerdens E, Uyttebroeck A, Boeckx N, de Bock CE, Cools J. - 2016 - Blood - Pubmed

JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model - Degryse S, de Bock CE, Cox L, Demeyer S, Gielen O, Mentens N, Jacobs K, Geerdens E, Gianfelici V, Hulselmans G, Fiers M, Aerts S, Meijerink JP, Tousseyn T, Cools J. - 2014 - Blood - Pubmed

Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia - De Keersmaecker K, Atak ZK, Li N, Vicente C, Patchett S, Girardi T, Gianfelici V, Geerdens E, Clappier E, Porcu M, Lahortiga I, Lucà R, Yan J, Hulselmans G, Vranckx H, Vandepoel R, Sweron B, Jacobs K, Mentens N, Wlodarska I, Cauwelier B, Cloos J, Soulier J, Uyttebroeck A, Bagni C, Hassan BA, Vandenberghe P, Johnson AW, Aerts S, Cools J. - 2013 - Nat Genet - Pubmed